منابع مشابه
Exosomes and cardiac repair after myocardial infarction.
Myocardial infarction is a leading cause of death among all cardiovascular diseases. The analysis of molecular mechanisms by which the ischemic myocardium initiates repair and remodeling indicates that secreted soluble factors are key players in communication to local and distant tissues, such as bone marrow. Recently, actively secreted membrane vesicles, including exosomes, are being recognize...
متن کاملGrowth differentiation factor 5 regulates cardiac repair after myocardial infarction.
OBJECTIVES The aim of this study was to examine the function of the bone morphogenic protein growth differentiation factor 5 (Gdf5) in a mouse model of myocardial infarction (MI). BACKGROUND The Gdf5 has been implicated in skeletal development, but a potential role in the heart had not been studied. METHODS The Gdf5-knockout (KO) and wild-type (WT) mice were subjected to permanent left ante...
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One of the most important therapeutic targets of current cardiology practice is to determine optimal strategies for the minimization of myocardial necrosis and optimization of cardiac repair following an acute myocardial infarction. Myocardial necrosis after acute myocardial infarction induces complement activation and free radical generation, triggering a cytokine cascade initiated by tumor ne...
متن کاملInjectable Hydrogels for Cardiac Tissue Repair after Myocardial Infarction
Cardiac tissue damage due to myocardial infarction (MI) is one of the leading causes of mortality worldwide. The available treatments of MI include pharmaceutical therapy, medical device implants, and organ transplants, all of which have severe limitations including high invasiveness, scarcity of donor organs, thrombosis or stenosis of devices, immune rejection, and prolonged hospitalization ti...
متن کاملCardiac repair with allogeneic mesenchymal stem cells after myocardial infarction.
Over the past decade, use of autologous bone marrow-derived mononuclear cells (BMCs) has proven to be safe in phase-I/II studies in patients with myocardial infarction (MI). Taken as a whole, results support a modest yet significant improvement in cardiac function in cell-treated patients. Skeletal myoblasts, adipose-derived stem cells, and bone marrow-derived mesenchymal stem cells (MSCs) have...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2016
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmcibr1512011